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View abstract. Zuardi AW, Crippa JA, Hallak JE, et al. Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug. Braz J Med Biol Res 2006;39(4):421-9. View abstract. Zuardi AW, Morais SL, Guimaraes FS, Mechoulam R. Antipsychotic effect of cannabidiol. J Clin Psychiatry 1995;56(10):485-6. View abstract. Zuardi AW. Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action.

View abstract. Ames, F. R. and Cridland, S. Anticonvulsant effect of cannabidiol. S.Afr. Med. J. 1-4-1986;69(1):14. View abstract. Barnes, M. P. Sativex: clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain. Expert. Opin. Pharmacother. 2006;7(5):607-615. View abstract. Collin, C., Davies, P., Mutiboko, I. K., and Ratcliffe, S.



Eur. J.Neurol. 2007;14(3):290-296. View abstract. Collin, C., Ehler, E., Waberzinek, G., Alsindi, Z., Davies, P., Powell, K., Notcutt, W., O'Leary, C., Ratcliffe, S., Novakova, I., Zapletalova, O., Pikova, J., and Ambler, Z. A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis.

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Res. 2010;32(5):451-459. View abstract. Consroe, P., Kennedy, K., and Schram, K. Assay of plasma cannabidiol by capillary gas chromatography/ion trap mass spectroscopy following high-dose repeated daily oral administration in humans. Pharmacol Biochem. Behav. 1991;40(3):517-522. View abstract. Consroe, P., Laguna, J., Allender, J., Snider, S., Stern, L., Sandyk, R., Kennedy, K., and Schram, K.

Pharmacol Biochem. Behav. 1991;40(3):701-708. View abstract. Crippa, J. A., Zuardi, A. W., Garrido, G. E., Wichert-Ana, L., Guarnieri, R., Ferrari, L., Azevedo-Marques, P. M., Hallak, J. E., Mc, Guire, P. K., and Filho, Busatto G. Effects of cannabidiol (CBD) on regional cerebral blood flow. Neuropsychopharmacology 2004;29(2):417-426. View abstract. Crippa, J.

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W., Martin-Santos, R., Bhattacharyya, S., Atakan, Z., Mc, Guire, P., and Fusar-Poli, P. Cannabis and anxiety: a critical review of the evidence. Hum. Psychopharmacol. 2009;24(7):515-523. View abstract. Cunha, J. M., Carlini, E. A., Pereira, A. E., Ramos, O. L., Pimentel, C., Gagliardi, R., Sanvito, W. L., Lander, N., and Mechoulam, R.

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Pharmacology 1980;21(3):175-185. View abstract. Harvey, D. J., Samara, E., and Mechoulam, R. Comparative metabolism of cannabidiol in dog, rat and man. Pharmacol Biochem. Behav. 1991;40(3):523-532. View abstract. Iuvone, T., Esposito, G., Esposito, R., Santamaria, R., Di Rosa, M., and Izzo, A. A. Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells.

2004;89(1):134-141. View abstract. Massi, P., Vaccani, A., Bianchessi, S., Costa, B., Macchi, P., and Parolaro, D. The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells. Cell Mol. Life Sci. 2006;63(17):2057-2066. View abstract. Massi, P., Vaccani, A., Ceruti, S., Colombo, A., Abbracchio, M. P., and Parolaro, D.

J Pharmacol Exp. Ther. 2004;308(3):838-845. View abstract. Ohlsson, A., Lindgren, J. E., Andersson, S., Agurell, S., Gillespie, H., and Hollister, L. E. Single-dose kinetics of deuterium-labelled cannabidiol in man after smoking and intravenous administration. Biomed. Environ Mass Spectrom. 1986;13(2):77-83. View abstract. Srivastava, M. D., Srivastava, B. I., and Brouhard, B.

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Immunopharmacology 1998;40(3):179-185. View abstract. Trembly B, Sherman M. Double-blind clinical study of cannabidiol as a secondary anticonvulsant. Marijuana '90 International Conference on Cannabis and Cannabinoids 1990;2:5. Wade, D. T., Collin, C., Stott, C., and Duncombe, P. Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis.

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Scler. 2010;16(6):707-714. View abstract. Wade, D. T., Makela, P., Robson, P., House, H., and Bateman, C. Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients. Mult. Scler. 2004;10(4):434-441. View abstract. Wade, D. T., Robson, P., House, H., Makela, P., and Aram, J.

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Clin. Rehabil. 2003;17(1):21-29. View abstract. Watzl, B., Scuderi, P., and Watson, R. R. Marijuana components stimulate human peripheral blood mononuclear cell secretion of interferon-gamma and suppress interleukin-1 alpha in vitro. Int J Immunopharmacol. 1991;13(8):1091-1097. View abstract. Weiss, L., Zeira, M., Reich, S., Har-Noy, M., Mechoulam, R., Slavin, S., and Gallily, R.

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Autoimmunity 2006;39(2):143-151. View abstract. Zuardi, A. W., Shirakawa, I., Finkelfarb, E., and Karniol, I. G. Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects. Psychopharmacology (Berl) 1982;76(3):245-250. View abstract. "GW Pharmaceuticals plc and Its U.S. Subsidiary Greenwich Biosciences, Inc. Announce That EPIDIOLEX® (cannabidiol) Oral Solution Has Been Descheduled And Is No Longer A Controlled Substance." GW Pharmaceuticals, 6 April 2020.

gwpharm.com/node/11356/pdf. Press release. 97021 Jadoon KA, Ratcliffe SH, Barrett DA, et al. Efficacy and safety of cannabidiol and tetrahydrocannabivarin on glycemic and lipid parameters in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel group pilot study. Diabetes Care. 2016 Oct;39(10):1777-86. View abstract. Agriculture Improvement Act, S. 10113, 115th Cong.

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